Abstract：As one of the most economically developed and densely populated regions in China, Taihu Lake Basin is also highly prone to typhoon induced natural disasters, with averagely 3.7 typhoons landing or impacting the basin. The conflicts between flood prevention and drainage restriction by tides of the East China Sea make the typhoon defense in Taihu Lake Basin a difficult task. According to these characteristics, Taihu Lake Basin Authority has taken comprehensive measures in recent years and made remarkable social and economic achievements. The measures include developing the information construction vigorously, strengthening the technical support, highlighting the projects scheduling and improving the typhoon defense capability. This paper focuses on the situation of typhoon defense work in Taihu Lake Basin, and the main practices taken by Taihu Lake Basin Authority, especially the application of information technology in this process.