Abstract: As a new type of river regulation structure,permeable pile dikes has been applied in the lower reaches of the Yellow River as a non-rescue dikes because of its unique effect of slow flow and sedimentation.The permeability of different permeable pile dikes has been determined during construction.However,in the actual operation process,the permeable pile dikes have been worn and displaces to varying degrees under complex water flow,resulting in a large difference between the pile dikes and the design working condition.Therefore,taking Dong'an Permeable Pile Dike project as the research object,according to the hydrological data of Huayuankou station,a two-dimensional hydrodynamic model of Dong'an project is constructed by using MIKE21 FM software for the simulation from January 1 to April 12,2021,and the measured data on April 12 were used to verify the model.The results show that the maximum error between the simulated section velocity and the measured section velocity is about 8.55%,and the simulation results are satisfactory;MIKE21 FM software has good applicability for river hydrodynamic simulation of Dong'an project.The research results can provide reference for the safe operation of permeable pile dikes.