Abstract: Hainan Province is prone to frequent natural disasters, and the risk of natural disasters is becoming increasingly prominent. In order to enhance the assessment capacity of natural disaster losses in Hainan Province, and scientifically determine the degree of disaster losses, a comprehensive disaster index is introduced, a disaster loss assessment model is developed based on the Analytic Hierarchy Process to quantitatively analyze the relationship between the comprehensive disaster index and comprehensive disaster losses. The results show that the disaster loss assessment model has passed the consistency test, indicating that the proportion of each evaluation factor in the comprehensive disaster loss is relatively consistent with the actual situation. The comprehensive disaster losses in Hainan Province are mainly direct economic losses and the number of severely damaged houses, accounting for a cumulative proportion of 54%. The extreme values of the comprehensive disaster index correspond to the extreme values of disaster losses in various regions over the years. The comprehensive index of disaster situation in Hainan Province is showing an overall decreasing trend year by year. It can provide a basis for disaster prevention, reduction, and relief management departments to evaluate the degree of disaster losses and post disaster insurance payment.